约氏乳杆菌

Lactobacillus johnsonii    LBJ456^®     菌株典藏编码：M20191013

【功能性/Effects】

减少系统性炎症

降低基因毒性

【作用机理/Mechanism of Action】

减少宿主体内促炎性细胞因子IL-1β和IFN-β水平，同时提高抗炎细胞因子TGFβ和IL-10水平，从而减少系统性炎症的发生，进而减少基因毒性。

【参考文献/References】

1. Cancer risk reduction through active management of genotoxicity

2.Intestinal inflammation induces genotoxicity to extraintestinal tissue and cell types in mice

3.A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period